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Worldwide approximately 240 million individuals have chronic hepatitis B. The main complications of the infection are cirrhosis and hepatocellular carcinoma. As a result of these complications, approximately 600,000 deaths are recorded annually.

In countries with increased endemicity (the prevalence of HBsAg is over 8%), and most cases occur at the age of infants and toddlers.

In Romania, in 2014, were registered 247 cases of acute infection and 19 chronic infection. A decrease in the total number of cases compared to previous years (2013-302 cases, 2012-361 cases) is observed. In Europe, in 2014, a total of 22,442 cases were reported, with an average incidence of 4.2 to 100,000 inhabitants, ranging from 0.1 in Romania to 17.3 in Sweden. The rate of chronic infections increased from 5.7 to 100,000 inhabitants in 2006 to 9.8 in 2014. This data originated from official reporting data.

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