TGP or alanine aminotransferase (ALT) is part of the Transferazelor class and catalyzes the reversible reaction of transferring an amino group from alanine to Alpha-cetoglutarat; The products of this transmemory reaction are pyruvic acid and glutamate.

TGP is synthesized mostly in the liver but also in myocardial, kidney and skeletal muscles.  Its intracellular localization is predominantly Citosolică

TGP is a marker of liver cytolysis, determination of its concentration allows diagnosis and monitoring of liver disease.  In monitoring liver disease The serum concentration of TGP is evaluated together with the concentration of TGO.  TGP is more specific to the diagnosis of liver disease than TGO.

The serum levels of transaminases vary depending on the number of affected cells, the severity of the damage of each cell, the speed with which the lesion and the speed of elimination from the serum (half-life) of the enzymes have occurred.

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