Anti-HBs appear after HBeAg disappearance and remain detectable for a long time1. Indicates a decrease in the degree of infectivity and suggests a good prognosis for resolution of acute infection. Combination with anti-HBc, in the absence of AgHBs and anti-HBs, confirms the diagnosis of recent acute infection (2-16 weeks).

Anti-HBe detection is not recommended for determining the prevalence of HBV infection, as anti-HBe are found to be much less common than anti-HBc or anti-HBs antibodies. Virtually all anti-HBe positive sera are also positive anti-HBc.

Both HBeAg and HBeAg test are only recommended for HBeAg positive sera3. During interferon therapy, the disappearance of HBe antigen and the occurrence of anti-HBe antibodies are a favorable prognostic element2.

Bibliography

Laboratory Synevo. References specific to the working technology used 2010. Ref Type: Catalog.
Lothar Thomas. Hepatitis B. In Clinical Laboratory Diagnostics – Use and Assessment of Clinical Laboratory Results. TH-Books Verlagsgesellschaft mbH, Frankfurt / Main, Germany, 1 Ed., 1998, 1269-1270.
Wallach J. Hepatobiliary and pancreatic disorders. In Interpretation of Diagnostic Tests. Ed. Of Medical Sciences, Romania, Ed., 2001, 313-317.

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