Immunological tolerance is the process of active and specific inhibition of the immune response to an endogenous or exogenous antigen, which is normally known to be able to trigger a humoral or cellular immune response. Thus the antigen can have two qualities apparent the contrary: it may trigger an immune response manifested by antibody production or by activating T lymphocytes, in which case it is considered immunogenic, or under certain conditions may inhibit the immune response expected, in which case they behave like tolerogen.

Immunological tolerance should not be understood as simply lack of immune response, but on the contrary an active inhibition of the immune response. A certain antigen adopts one of the two qualities (immunogenic, Tolerogen) depending on certain peculiarities of antigen (nature, concentration, persistence of antigender) or the receptor body (the penetration path, the degree of imunocompetenţă).

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