Hepatitis B virus heals totally in 90% of patients within 12 weeks with the disappearance of AgHBs and the occurrence of anti-HBs protective antibodies¹.

Anti-HBs are present in the serum 4-6 months after disease onset and remain detectable in 80-90% of patients with the virus removed⁴.

The presence of detectable HBs without HBs indicates healing after a HBV infection, absence of infectivity and immunity to a subsequent HBV infection; in case of exposure, the patient does not require gamaglobulin administration; his blood can be transfused^1;4.

Anti-HBs also occur after passive transfusion^1;4.

The presence of anti-HBs can be used to demonstrate the effectiveness of immunization programs. Appear to 90% of healthy adults after 3 immunization doses; 30-50% of them lose antibodies after 7 years and require revaccination^1;4.

Bibliography

1. Jacques Wallach. Hepatitis B (Anti-HBs). In the Interpretation of Diagnostic Tests. Ed. Of Medical Sciences, Romania, Ed. 7, 2001, 312-315.
2. Laboratory Synevo. References specific to the working technology used 2010. Ref Type: Catalog.
3. Laboratory Corporation of America. Directory of Services and Interpretive Guide. Hepatitis B Surface Antibody. www.labcorp.com 2010. Ref Type: Internet Communication.
4. Lothar Thomas. Hepatitis B (Antibodies to HBsAg). In Clinical Laboratory Diagnostics – Use and Assessment of Clinical Laboratory Results. TH-Books Verlagsgesellschaft mbH, Frankfurt / Main, Germany, 1 Ed., 1998, 1266-1268.

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