Multicentre Study
TORCH Acronym:
1. Toxoplasmosis (T)
2. other = Other (O)
Listeriosis
Syphilis
Chicken pox
Parvovirus B19
Hiv
3. Rubella (R)
4. Cytomegalovirus Infection (C)
5. Herpes simplex virus infection (H)
Purpose
Evaluating the consequences of TORCH infections in pregnant and newborn
Objectives
- Identification and description of cases of newborns with congenital TORCH infections
- Identification of spontaneous abortion / death in utero cases caused by confirmed TORCH infection
- Identification of therapeutic abortion cases due to anomalies caused by TORCH infections
Study Protocol
A. It will retrospectively analyze the cases of congenital TORCH infections diagnosed in newborns as well as those diagnosed in utero that have been completed with spontaneous or therapeutic abortion.
The search for cases will be carried out in the hospital database using the ICD coding.
ICD coding
Congenital infection | ICD code |
|---|---|
B. There will be prospective analysis of the cases of TORCH congenital infections diagnosed in newborns as well as those diagnosed in utero that have been completed with spontaneous or therapeutic abortion.
They will follow and re-evaluate the symptomatic and asymptomatic newborns at 3 months, 6 months and 1 year of birth according to etiology.
Note the following parameters shall be made in the table attached:
- G, T, PC, PT, PA, PC birth
- G, T, PC, PT, PA, current PC
Depending on etiology – specialized investigations
Toxoplasmosis
- HLG, transaminases, urea, creatinine, urine analysis
- Ophthalmological Examination: Unilateral macular scars
- Cerebral imaging: Small focal cerebral calcifications, hydrocephalus, cortical atrophy
- Hearing testing
Syphilis
- HLG, transaminases, urea, creatinine, urine analysis
- Eye Exam
- Cerebral imaging
- Hearing testing
- Long-bone X-rays
- VDRL
Chickenpox
- HLG, transaminases, urea, creatinine, urine analysis
- Eye Exam
- Cerebral imaging
- In case of gastro-esophageal reflux, gastroenterological consultation
Zika
- HLG, transaminases, urea, creatinine, urine analysis, glucose
- FT4, TSH at 2 weeks and 3 months
- Eye Exam
- Cerebral imaging/Neurological Consult
- Hearing testing
HBV
- HLG, transaminases, urea, creatinine, urine analysis
Infants who received specific Ig and 2 doses of vaccine at birth
- HBsAg and Ac anti Hbs at 9 months and 12 months or 2 months after the last dose
HCV
- HLG, transaminases, urea, creatinine, urine analysis
- Ac HCV
- PCR RNA HCV
Rubella
- HLG, transaminases, urea, creatinine, urine analysis, glucose, FT4, TSH
- Eye Exam
- Cerebral imaging/Neurological Consult
- Hearing testing
- Cardiology Consult
CMV
- HLG, transaminases, total bilirubin and fractioned, urea, creatinine, urine analysis
- Eye Exam
- Cerebral imaging/Neurological consult in case of convulsion/spasticity
- Hearing testing
- Abdominal ultrasound
- Viremia CMV
HSV
A. Newborns from mothers with active or historical lesions of genital HSV but without active birth injuries should be followed for clinical signs of HSV infection until the age of 6 weeks:
- Veziculara eruption
- Conjunctival lesions
- Sepsis
- Irritability
B. New symptomatic born
- HLG, transaminases, total bilirubin and fractioned, urea, creatinine, urine analysis
- Eye Exam
- Cerebral imaging/Neurological Consult
- Hearing testing
- Monitoring of skin recurrent
Criteria for inclusion in the study
A.) New born
- Newborn symptomatic diagnosed with TORCH infection
- Newborn asymptomatic originating from the mother:
- With seroconversion during pregnancy
- In which serological status is not known preconception, but is diagnosed during pregnancy with acute infection from the TORCH palette
- Known preconception with HVB, HVC, HIV, syphilis, toxoplasmosis
B.) Pregnant
- Spontaneous abortion/death in utero caused by confirmed TORCH infection
- Therapeutic abortion performed as a result of a TORCH infection
Exclusion criteria
A.) Newborn
- With congenital or neonatal infection or sepsis of unknown etiology
B.) Pregnant
- Miscarriage/therapeutic of unspecified etiology
Data collection
- The requested data will be inserted into the Excel files.
- For newborns, a Word document with epicrisis (discharge) will be completed
- Existing imaging data (pictures of newborn, radiological investigations) will be annexed to the dedicated folder, with its name
About Corneliu Zaharia
