The highlighting of IgM antiviral antibodies to the newborn in the first week can be an useful tool in the diagnosis of congenital infection, but direct techniques (PCR or viral isolation) are much more accurate.

The absence of IgM antibodies does not preclude the possibility of a congenital infection (10-30% of newly-infected infants do not develop specific IgM antibodies), therefore the isolation of the virus during the first week of life remains the best way to diagnose congenital infection.

The use of the PCR technique of viral genome detection in amniotic fluid may be useful for the diagnosis of fetal infection after week 21 of pregnancy.

The determination of IgG antibodies is useful in the screening of the immune status, especially for the pregnant woman, allowing the identification of the seronegative individuals-those who have not yet had that viral infection, to which can be applied prophylactic measures. This situation in the pregnant woman involves increased risk of getting the primoinfection during the current pregnancy.

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